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Cerebrovascular disease and stroke

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. The physiological and pathological significance of the arachnoid membrane (AM) is still unknown. In this study, we investigated various characteristics of the AM, focusing on the influence of inflammation and ...

    Authors: Hime Suzuki, Takeshi Mikami, Naotoshi Iwahara, Yukinori Akiyama, Masahiko Wanibuchi, Katsuya Komatsu, Rintaro Yokoyama, Tsukasa Hirano, Ryusuke Hosoda, Yoshiyuki Horio, Atsushi Kuno and Nobuhiro Mikuni

    Citation: BMC Neurology 2021 21:169

    Content type: Research article

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  2. We report on a patient with an intracerebral hemorrhage (ICH), who showed delayed development of aphasia, which was demonstrated via follow up diffusion tensor tractography (DTT) to be related to neural degene...

    Authors: Min Jye Cho and Sung Ho Jang

    Citation: BMC Neurology 2021 21:166

    Content type: Case report

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  3. Patients who have been successfully treated for an aneurysmal subarachnoid hemorrhage (aSAH) often retain multiple health complaints, including mood disorders, cognitive complaints, fatigue, and problems with ...

    Authors: Edith Nobels-Janssen, Inger L. Abma, Wim I. M. Verhagen, Ronald H. M. A. Bartels, Philip J. van der Wees and Jeroen D. Boogaarts

    Citation: BMC Neurology 2021 21:162

    Content type: Research article

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  4. The initial CT blend sign is an imaging marker that has been used to predict haematoma expansion and poor outcomes in patients with small-volume intracerebral haemorrhage (ICH). However, the association of the...

    Authors: Xu Yang, Yan Zhu, Linshan Zhang, Likun Wang, Yuanhong Mao, Yinghui Li, Jinbiao Luo and Guofeng Wu

    Citation: BMC Neurology 2021 21:160

    Content type: Research article

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  6. Stroke incidence is reportedly increasing in younger populations, although the reasons for this are not clear. We explored possible reasons by quantifying trends in neurologically focused emergency department ...

    Authors: Abhinav J. Appukutty, Lesli E. Skolarus, Mellanie V. Springer, William J. Meurer and James F. Burke

    Citation: BMC Neurology 2021 21:152

    Content type: Research article

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  9. The onset time of intracerebral hemorrhage (ICH) may be closely related to the working style and living habits of people, which are determined by different income sources in China. Therefore, the purpose of ou...

    Authors: Yan-Yue Wang, Ning Yan, En-Yuan Wang and Yun-Tao Pu

    Citation: BMC Neurology 2021 21:140

    Content type: Research article

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  10. Pneumonia is related to poor prognosis in acute ischemic stroke (AIS), and its risk might be higher in atrial fibrillation (AF) related AIS with elevated plasma D-dimer. The aim of our study was to investigate...

    Authors: Xu Yang, Taoli Lu, Zhanli Qu, Yi Zhang, Pingping Liu and Ying Ma

    Citation: BMC Neurology 2021 21:137

    Content type: Research article

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  11. Stroke is a leading cause of disability worldwide and the cardiovascular fitness levels of stroke survivors are diminished to an extent that impairs functioning and activities of daily living performance. Whil...

    Authors: Hanna Reynolds, Sarah Steinfort, Jane Tillyard, Sarah Ellis, Alan Hayes, Erik D. Hanson, Tissa Wijeratne and Elizabeth H. Skinner

    Citation: BMC Neurology 2021 21:132

    Content type: Research article

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  12. The computed tomography angiography (CTA) spot sign is a validated predictor of hematoma expansion and 30-day mortality in intracerebral hemorrhage (ICH). However, whether the spot sign predicts worse function...

    Authors: Wen-Che Tseng, Yu-Fen Wang, Tyng-Guey Wang and Ming-Yen Hsiao

    Citation: BMC Neurology 2021 21:131

    Content type: Research article

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  14. Although increasing evidence showed the correlations between white matter hyperintensities (WMHs) and cognitive impairment, the relationship between them is still modest. Many researchers began to focus on the...

    Authors: Zhi-gang Min, Hai-rong Shan, Long Xu, Dai-hai Yuan, Xue-xia Sheng, Wen-chao Xie, Ming Zhang, Chen Niu, Tahir Mehmood Shakir and Zhi-hong Cao

    Citation: BMC Neurology 2021 21:128

    Content type: Research article

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  16. The effect of hypothermia on large hemispheric infarction (LHI) remains controversial. Our study aimed to explore the therapeutic outcomes of decompressive craniectomy (DC) combined with hypothermia on LHI.

    Authors: Linlin Fan, Yingying Su, Yan Zhang, Hong Ye, Weibi Chen and Gang Liu

    Citation: BMC Neurology 2021 21:114

    Content type: Research article

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  17. Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome characterized by the dissociation of motor and language functions. Here, we present a case of GAWH with the patient later regaining speech fl...

    Authors: Ya-Chi Chuang, Chuan-Ching Liu, I-Ching Yu, Yu-Lin Tsai and Shin-Tsu Chang

    Citation: BMC Neurology 2021 21:111

    Content type: Case report

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  18. Although the association between periventricular target collateral anastomosis and recurrent ipsilateral hemorrhage has been evaluated in adult patients with moyamoya disease (MMD), no studies have investigate...

    Authors: Jian Wang, Qingrong Zhang, Xia Lu, Qun Liang, Yi Wang, Yichao Zhu, Shijie Na, Fang Liu, Liming Tang and Yongbo Yang

    Citation: BMC Neurology 2021 21:102

    Content type: Research article

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  19. Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, ...

    Authors: Jung-Won Choi, In Woo Ryoo, Jun Yeong Hong, Kyung-Yul Lee, Hyo Suk Nam, Won Chan Kim, Seung-Hun Oh, Jaeku Kang, Hoi Young Lee, Sang-Jun Na, Ji Hoe Heo and Kee Ook Lee

    Citation: BMC Neurology 2021 21:91

    Content type: Research article

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  20. Neurocognitive disorder (NCD) is common in stroke survivors. We aimed to identify clinically accessible imaging markers of stroke and chronic pathology that are associated with early post-stroke NCD.

    Authors: Till Schellhorn, Eva Birgitte Aamodt, Stian Lydersen, Stina Aam, Torgeir Bruun Wyller, Ingvild Saltvedt and Mona Kristiansen Beyer

    Citation: BMC Neurology 2021 21:89

    Content type: Research article

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  21. The mu-opioid agonist methadone is administered orally and used in opioid detoxification and in the treatment of moderate-to-severe pain. Acute oral methadone–use and –abuse have been associated with inflammat...

    Authors: Jonathan Repple, Svea Haessner, Andreas Johnen, Nils C. Landmeyer, Andreas Schulte-Mecklenbeck, Marc Pawlitzki, Heinz Wiendl and Gerd Meyer zu Hörste

    Citation: BMC Neurology 2021 21:85

    Content type: Case report

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  22. In contrast to the hospital setting, today little work has been directed to the definition, measurement, and improvement of the quality of out-patient medical and therapeutic care. We developed a set of indica...

    Authors: I. Padberg, S. Heel, P. Thiem, A. Diebel, E. Mordhorst, U. Strohmeyer and A. Meisel

    Citation: BMC Neurology 2021 21:76

    Content type: Research article

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  23. Systemic cardiac hypoperfusion is a well-acknowledged contributor to ischemic leukoencephalopathy. However, it has remained elusive how atherosclerosis-mediated cardiac remodelling modifies cerebral perfusion ...

    Authors: Xiaodong Chen, Danli Lu, Ning Guo, Zhuang Kang, Ke Zhang, Jihui Wang, Xuejiao Men, Zhengqi Lu and Wei Qiu

    Citation: BMC Neurology 2021 21:67

    Content type: Research article

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  25. The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to...

    Authors: Liang-Yu Huang, Fu-Rong Sun, Jian-Jun Yin, Ya-Hui Ma, Hong-Qi Li, Xiao-Ling Zhong, Jin-Tai Yu, Jing-Hui Song and Lan Tan

    Citation: BMC Neurology 2021 21:56

    Content type: Research article

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  26. Isolated spinal artery aneurysms are extremely rare, and their pathogenesis, clinical presentation, and treatment strategies are poorly established. We report only the second case of a patient with an isolated...

    Authors: Alexander Tenorio, Brandon B. Holmes, Adib A. Abla, Matthew Amans and Karl Meisel

    Citation: BMC Neurology 2021 21:52

    Content type: Case report

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  27. Approximately 10% of patients would develop symptomatic intracranial hemorrhage (sICH) after endovascular therapy. The aim of our study was to explore the ability of hypersensitive C-reactive protein-albumin r...

    Authors: Qiang Peng, Jiankang Hou, Siyu Wang, Feng Zhou, Yan E, Wei Wang, Ting Huang, Meng Wang, Shi Huang, Junshan Zhou, Nihong Chen and Yingdong Zhang

    Citation: BMC Neurology 2021 21:47

    Content type: Research article

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  28. Endovascular procedures with liquid embolic agents such as ethylene-vinyl alcohol (EVOH) copolymers are indicated before surgical treatment of cervical paraganglioma. Consequently, these agents are now availab...

    Authors: Santiago Moreno-Paredes, Laura Rodríguez-Alcalá, Juan Martín-Lagos Martínez, Nicolás Müller Locatelli, Cristina Vázquez López, José Luis Vargas Fernández and Álvaro Cabrera Peña

    Citation: BMC Neurology 2021 21:45

    Content type: Case report

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  29. Ambulatory and balance functions are important for maintaining general health in humans. Gait analysis allows clinicians and researchers to identify the parameters to be focused on when assessing balance and a...

    Authors: Min Cheol Chang, Byung Joo Lee, Na-Young Joo and Donghwi Park

    Citation: BMC Neurology 2021 21:38

    Content type: Research article

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  30. Hemorrhagic transformation (HT) is a serious neurological complication of acute ischemic stroke (AIS) after revascularization. The majority of AIS patients do not have atrial fibrillation (AF) which could also...

    Authors: Hao-Ran Cheng, Yun-Bin Chen, Ya-Ying Zeng, Yi-Ting Ruan, Cheng-Xiang Yuan, Qian-Qian Cheng, Hui-Jun Chen, Xiao-Qian Luan, Gui-Qian Huang and Jin-Cai He

    Citation: BMC Neurology 2021 21:36

    Content type: Research article

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  32. Internal carotid artery (ICA) stenosis has been recently reported to cause hemichorea, mainly in East Asia. The East Asian-specific p.R4810K variant of RNF213, a susceptibility gene for moyamoya disease (MMD), ac...

    Authors: Satoshi Hosoki, Takeshi Yoshimoto and Masafumi Ihara

    Citation: BMC Neurology 2021 21:32

    Content type: Case report

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  34. Hypothyroidism (HT) and carotid artery stenosis (CAS) are complications of radiotherapy (RT) in patients with head and neck cancer (HNC). The impact of post-RT HT on CAS progression remains unclear.

    Authors: Chi-Hung Liu, Joseph Tung-Chieh Chang, Tsong-Hai Lee, Pi-Yueh Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Ting-Yu Chang, Kuo-Lun Huang, Chien-Yu Lin, Kang-Hsing Fan and Yeu-Jhy Chang

    Citation: BMC Neurology 2021 21:30

    Content type: Research article

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  35. This observational study was performed to show the impact of complications and interventions during neurocritical care on the outcome after aneurysmal subarachnoid hemorrhage (SAH).

    Authors: Alexander Hammer, Frank Erbguth, Matthias Hohenhaus, Christian M. Hammer, Hannes Lücking, Markus Gesslein, Monika Killer-Oberpfalzer, Hans-Herbert Steiner and Hendrik Janssen

    Citation: BMC Neurology 2021 21:27

    Content type: Research article

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  36. Stroke is a major health problem around the world. Several studies have examine the influence of ambient temperature on incidence of stoke, but they reported different results for different types of stroke and...

    Authors: Mirjam Ravljen, Fajko Bajrović and Damjan Vavpotič

    Citation: BMC Neurology 2021 21:23

    Content type: Research article

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  37. Increasing evidences have showed that neuroimaging markers of SVD can predict the short-term outcome of acute ischemic stroke (AIS). It is unclear that whether neuroimaging markers of SVD are also associated w...

    Authors: Xuemei Chen, Lin Wang, Junying Jiang, Yuanyuan Gao, Rui Zhang, Xiaoyuan Zhao, Tingwen Shen, Qi Dai and Junrong Li

    Citation: BMC Neurology 2021 21:21

    Content type: Research article

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  38. The prevalence of carotid artery stenosis (CAS) in acute ischaemic stroke (AIS) patients is historically reported at 15–20%, but an up-to-date estimate is lacking. We hypothesise it is lower than historically ...

    Authors: Twan J van Velzen, Laurien S Kuhrij, Willeke F Westendorp, Diederik van de Beek and Paul J Nederkoorn

    Citation: BMC Neurology 2021 21:20

    Content type: Research article

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  39. Residual motor deficits of the upper limb in patients with chronic stroke are common and have a negative impact on autonomy, participation and quality of life. Music-Supported Therapy (MST) is an effective int...

    Authors: Jennifer Grau-Sánchez, Emma Segura, David Sanchez-Pinsach, Preeti Raghavan, Thomas F. Münte, Anna Marie Palumbo, Alan Turry, Esther Duarte, Teppo Särkämö, Jesus Cerquides, Josep Lluis Arcos and Antoni Rodríguez-Fornells

    Citation: BMC Neurology 2021 21:19

    Content type: Study protocol

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  40. Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg’s syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At ...

    Authors: Jing Wang, Pei Liu, Zhongzhong Liu, Ye Tian, Guilian Zhang, Jun Guo, Li Li, Zhiqin Liu, Zucheng Han, Wenjuan Lin, Xuemei Lin, Qingli Lu, Yan Liu, Qiaoqiao Chang and Songdi Wu

    Citation: BMC Neurology 2021 21:18

    Content type: Study protocol

    Published on:

  41. Adenomyosis, a benign gynecological disease, causes cerebral infarction. Similar to Trousseau’s syndrome, it elevates cancer antigen 125 (CA125) and D-dimer levels; causes hypercoagulability; and results in ce...

    Authors: Ryo Aiura, Sadayoshi Nakayama, Hroo Yamaga, Yu Kato and Hirotake Fujishima

    Citation: BMC Neurology 2021 21:14

    Content type: Case report

    Published on:

  42. Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported.

    Authors: Si-ying Song, Gary Rajah, Yu-chuan Ding, Xun-ming Ji and Ran Meng

    Citation: BMC Neurology 2021 21:9

    Content type: Case report

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  45. Stroke in adults aged between 18 and 64 years old is increasing significantly worldwide. Studies have reported that this group of young stroke survivors encounters enormous difficulties reintegrating into thei...

    Authors: Suzanne Hoi Shan Lo, Janita Pak Chun Chau, Kai Chow Choi, Edward Wai Ching Shum, Jonas Hon Ming Yeung and Siu Hung Li

    Citation: BMC Neurology 2021 21:3

    Content type: Study protocol

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  46. Cervicocerebral artery dissection is an important cause of ischemic stroke in young and middle-aged individuals. However, very few studies have compared the differential features between internal carotid arter...

    Authors: Yongjun Wu, Hongbin Chen, Shihui Xing, Shuangquan Tan, Xinran Chen, Yan Tan, Jinsheng Zeng and Jian Zhang

    Citation: BMC Neurology 2020 20:445

    Content type: Research article

    Published on:

  47. Although a central role of the thalamus for sleep regulation is undisputed, the exact localization of the crucial structures within the thalamus remains controversial.

    Authors: Peter Nørregaard Hansen, Thomas Krøigård, Nina Nguyen, Rune Vestergaard Frandsen, Poul Jørgen Jennum and Christoph P. Beier

    Citation: BMC Neurology 2020 20:442

    Content type: Case report

    Published on:

  48. Reducing prehospital delay plays an important role in increasing the thrombolysis rate in patients with stroke. Several studies have identified predictors for presentation ≤4.5 h, but few compared these predic...

    Authors: Matthias N. Ungerer, Loraine Busetto, Nima H. Begli, Katharina Riehle, Jens Regula and Christoph Gumbinger

    Citation: BMC Neurology 2020 20:441

    Content type: Research article

    Published on:

  49. Neuroinflammation plays an important role in the pathogenesis of acute ischemic stroke (AIS) and peripheral leukocyte counts have proved to be independent predictors of stroke severity and outcomes. Clinical s...

    Authors: Gabor Tarkanyi, Zsofia Nozomi Karadi, Zsofia Szabo, Istvan Szegedi, Laszlo Csiba and Laszlo Szapary

    Citation: BMC Neurology 2020 20:440

    Content type: Research article

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  50. A large-bore aspiration catheter can be employed for recanalization of acute basilar artery occlusion. Here we compare the results of mechanical thrombectomy using a stent retriever (SR) and manual aspiration ...

    Authors: Jin Wook Choi, Miran Han, Jung Hyun Park and Woo Sang Jung

    Citation: BMC Neurology 2020 20:434

    Content type: Research article

    Published on:

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